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August 25, 2025Frontiers in EndocrinologyOpen Access

An investigation of the pattern and mechanism of comorbidity in patients with Hashimoto’s thyroiditis

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Authors

CZCaihong ZhaoHXHuabao XiongJining Medical UniversityLZL. ZhuDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

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Overview

Analysis shows high comorbidity prevalence in Hashimoto’s thyroiditis patients, indicating risk factors and pathways involved.

Key Points

  • Comorbidity prevalence in Hashimoto’s thyroiditis was found to be 81.19%, emphasizing the need for better clinical care.
  • The core binary comorbidity identified was thyroid nodules, with additional risks linked to female gender and age.
  • Assessment employed association rule and logistic regression analyses to reveal significant comorbidity patterns and mechanisms.
  • Key pathways impacted include cancer pathways and the PI3K–Akt signaling pathway, suggesting specific therapeutic targets.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68af5d63ad7bf08b1eae090chttps://doi.org/10.3389/fendo.2025.1615095
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