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August 25, 2025Advanced Healthcare MaterialsOpen Access

Using High‐Throughput Screening to Identify Crosslinking Peptides That Control Cell‐Mediated Matrix Degradation

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Authors

YWYingjie WuSRSamuel J. RozansAMAbolfazl Salehi Moghaddam

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Overview

Novel peptides improve degradation control in extracellular matrix hydrogels, highlighting their role in cell dynamics.

Key Points

  • The optimized peptide KLVADLMASAE reduces degradation while maintaining cell viability and spreading.
  • KLVADLMASAE-crosslinked hydrogels demonstrate improved stiffness and less macroscopic degradation after 14 days.
  • A high-throughput approach combining proteomics and mass spectrometry identifies effective crosslinking peptides.
  • This research supports the development of hydrogels that mimic essential properties of the extracellular matrix.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68af5d63ad7bf08b1eae094bhttps://doi.org/10.1002/adhm.202501932
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