Modification of poly(Y-Dex-MBA) hydrogel by maleic anhydride and its use for the release of cephalexin and guaifenesin.

In this research, the surface of yellow dextrin was modified with maleic anhydride, and the hydrogel was formed using N, N-methylene bisacrylamide (MBA) as a crosslinker. Hydroxyl radicals were generated using the Fenton method, and then the hydroxyl radicals oxidized the remaining hydroxyl groups on the yellow dextrin to produce yellow dextrin radicals. Radical polymerization occurs due to the presence of two alkene groups at the ends of the(MBA) linker, which interact with the yellow dextrin radicals. The modified hydrogel was characterized using infrared spectroscopy(FTIR), proton nuclear magnetic resonance (HNMR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) for surface morphology. 40 mg of cephalexin and 60 mg of guaifenesin were loaded into 0.1 g of the modified hydrogel, separately for each. Finally, swelling and drug release tests were performed in different pH media, like phosphate buffer saline (PBS), at 37°C.Yellow dextrin is a polysaccharide of natural origin, a low-molecular-weight, with the chemical formula (C6H10O5) n. Yellow dextrin is produced by the hydrolysis of starch, or by the hydrolysis of starch