Analysis reveals plasma-treated arginine induces cell death in breast cancer cells, suggesting implications for treatment.
This study evaluated the selective cytotoxicity of plasma-treated arginine (PTA) in breast cancer (MCF-7) and normal mammary epithelial (MCF-10A) cells. Reactive oxygen and nitrogen species (RONS) generation in PTA correlated with initial arginine concentration. Under serum-free conditions, PTA induced acute cancer cell death, while serum-containing medium attenuated this effect. Notably, PTA suppressed MCF-7 viability for up to 72 hours without harming MCF-10A, suggesting delayed oxidative stress-mediated cytotoxicity. These results underscore the therapeutic potential of PTA and highlight the importance of medium conditions and extended observation periods in plasma medicine.
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Du et al. (2025) studied this question.
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