Synthesis of Poly‐Substituted Imidazo1,2‐aPyridines via a Double Annulation Strategy

Key Points

• The process yields densely functionalized imidazo[1,2-a]pyridine efficiently, supporting versatile applications in synthesis.
• Incorporating conjugate substitution, nucleophilic addition, and cycloisomerization forms three C─N bonds, enhancing complexity.
• Observations from the reaction of enaminonitrile with propargylamine demonstrate the effectiveness of the approach.
• These findings may facilitate the development of novel compounds in medicinal chemistry, expanding synthesis techniques.