Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy

Q: What type of study is this?

This is a In Vitro Study study.

M. JUNG; Sunhee Lee; Dohui Ku; D.‐H. KANG; Ikyon Kim

doi:10.1002/ajoc.70175

August 25, 2025Asian Journal of Organic Chemistry

Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy

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Key Points

The process yields densely functionalized imidazo[1,2-a]pyridine efficiently, supporting versatile applications in synthesis.
Incorporating conjugate substitution, nucleophilic addition, and cycloisomerization forms three C─N bonds, enhancing complexity.
Observations from the reaction of enaminonitrile with propargylamine demonstrate the effectiveness of the approach.
These findings may facilitate the development of novel compounds in medicinal chemistry, expanding synthesis techniques.

Implication

Domino process produces densely functionalized imidazo[1,2-a]pyridine in high yield, suggesting a new synthetic route.

Abstract

A highly efficient domino process consisting of conjugate substitution, nucleophilic addition, and cycloisomerization from the reaction of enaminonitrile with propargylamine allowed for a successive double ring closure to afford a densely functionalized imidazo[1,2‐ a ]pyridine through formation of three C─N bonds.

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Cite This Study

JUNG et al. (2025) studied this question.

synapsesocial.com/papers/68af5f13ad7bf08b1eae1dbf https://doi.org/10.1002/ajoc.70175

View Full Paper

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Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

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