Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 25, 2025Clinical and Experimental MedicineOpen Access

A novel prognostic signature integrating disulfidptosis- and ferroptosis-related genes in acute myeloid leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

HJHuihui JiangLLLiang LiTLTingting Liu

Discussion

Loading...

Member takes

Overview

This analysis reveals a prognostic signature in acute myeloid leukemia, indicating improved outcomes and treatment strategies based on immune infiltration and drug responses.

Key Points

  • The prognostic signature predicts survival and treatment response in acute myeloid leukemia patients, showing clinical relevance.
  • Kaplan–Meier survival analysis demonstrated the signature's accuracy in discriminating high-risk from low-risk patients as per immune infiltration.
  • Assessment involved data from the TCGA-LAML dataset, employing advanced statistical methods including Cox regression analysis.
  • This approach may enhance personalized therapy options for AML patients, highlighting the importance of disulfidptosis and ferroptosis pathways.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68af5f13ad7bf08b1eae1e39https://doi.org/10.1007/s10238-025-01670-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of potential ferroptosis hub genes in acute-on-chronic liver failure based on bioinformatics analysis and experimental verification2023 · 7 citations
  2. 2‘Acute myeloid leukemia: a comprehensive review and 2016 update’2016 · 1,363 citations
  3. 3Survival and cure of acute myeloid leukaemia in <scp>E</scp>ngland, 1971‐2006: a population–based study2013 · 210 citations
  4. 4Prognostic significance of ferroptosis-related genes and their methylation in AML2021 · 27 citations