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August 25, 2025Scientific ReportsOpen Access

Targeting ADAM17 to dampen dendritic cell-mediated type 2 immune responses and airway inflammation associated with allergic asthma

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Authors

AJAnil K. JaiswalBioLegend (United States)DMDmitriy MinondNova Southeastern UniversityAMAmarjit Mishra

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Implication

In vivo approach reveals that targeting ADAM17 suppresses airway inflammation in allergic asthma, indicating potential therapy options.

Key Points

  • Targeting ADAM17 reduces eosinophilic airway inflammation associated with type 2 allergic asthma, offering therapeutic promise.
  • DC-specific ADAM17 ablation showed a decrease in metabolic activity and immune function, reducing allergic responses.
  • Utilizing a small-molecule inhibitor enhanced protection against type 2 allergic responses to house dust mites in wild-type mice.
  • Findings highlight ADAM17 as a critical modulator in airway inflammation, suggesting avenues for future treatment of asthma.

Cite This Study

Jaiswal et al. (2025) studied this question.

synapsesocial.com/papers/68af5f13ad7bf08b1eae1fc9https://doi.org/10.1038/s41598-025-14569-w
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  1. 1Combination fixed-dose β agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review2021 · 31 citations
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  3. 3Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen2010 · 630 citations
  4. 4SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes2015 · 22 citations