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August 26, 2025Frontiers in MedicineOpen Access

Application of metagenomics sequencing to diagnose paralytic rabies with stroke-like onset: a case report

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The patient exhibited rapid deterioration after stroke-like symptoms onset, leading to emergency interventions.
Metagenomic sequencing identified nine rabies virus sequences with 99% genetic match, improving diagnostic accuracy.
Lumbar puncture revealed rabies through cerebrospinal fluid analysis using next-generation sequencing.
mNGS technology enhances sensitivity and shortens detection time compared to traditional methods like PCR.

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Case report showcases metagenomics sequencing improving diagnosis of rabies in a 58-year-old man with stroke symptoms.

Lin et al. (2025) studied this question.

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