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August 26, 2025Frontiers in PharmacologyOpen Access

Natural products as therapeutics for malignant melanoma: preclinical evidence and mechanism

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Authors

HGHongjin GaoJHJianli HuangDZDengfeng Zhang

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Overview

Review demonstrates the inhibitory effects of natural products on melanoma, highlighting apoptosis-inducing signaling pathways.

Key Points

  • Natural products inhibit melanoma growth and metastasis through various signaling pathways, indicating their therapeutic potential.
  • Key mechanisms include apoptosis induction via caspase-dependent pathways and modulation of Wnt/β-catenin signaling.
  • This review categorizes bioactive compounds such as capsaicin and resveratrol based on their action mechanisms against melanoma cells.
  • Natural product-based therapies could address current cancer treatment limitations, suggesting new clinical applications.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68af61fdad7bf08b1eae276fhttps://doi.org/10.3389/fphar.2025.1641838
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  5. 5Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach2024 · 1 citations