Mass spectrometric imaging and quantitative analysis of the in vivo biodistribution of trastuzumab using a rhodium(III) sarcophagine complex

Natasha Patel; Truc Le-Buu Pham; Arshiya Banu; Alexander Griffiths; Brett M. Paterson; George Firth; Alexander P. Morrell; Clíona McMahon; Nicholas J. Long; James R. Baker; Vijay Chudasama; Michelle Ma

doi:10.1039/d5qi00731c

January 1, 2025Inorganic Chemistry FrontiersOpen Access

Mass spectrometric imaging and quantitative analysis of the in vivo biodistribution of trastuzumab using a rhodium(III) sarcophagine complex

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Key Points

Mass spectrometric imaging showed effective profiling of trastuzumab biodistribution.
The analysis utilized rhodium(III) sarcophagine complexes for enhanced sensitivity in imaging.
Mass cytometry employed stable metal isotopes for accurate quantification of protein expression.
Findings support advanced imaging techniques for better understanding of drug distribution in biological systems.

Implication

Mass cytometry reveals trastuzumab biodistribution in vivo, suggesting enhanced imaging with metal isotopes.

Abstract

Mass cytometry with antibodies labelled with stable metal isotopes enables both sensitive imaging and the quantification of protein expression in biological samples. Typically, these specimens are exposed to a panel...

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Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2b22 https://doi.org/10.1039/d5qi00731c

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Mass spectrometric imaging and quantitative analysis of the in vivo biodistribution of trastuzumab using a rhodium(III) sarcophagine complex

Key Points

Implication

Abstract

Discussion

Cite This Study

Mass spectrometric imaging and quantitative analysis of the in vivo biodistribution of trastuzumab using a rhodium(III) sarcophagine complex

Key Points

Implication

Abstract

Discussion

Cite This Study

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