July 2, 2025Revista Brasileira de Física MédicaOpen Access

Energy Deposition and DNA Damage Analysis of Protons and Alpha Particles simulated with FLUKA applied to a cellular model

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More particles reached the nucleus as beam energy increased, showing significant variation with alpha particles.
Energy deposition analyses indicated that the depth of maximum energy deposition increases with kinetic energy, particularly for alpha particles.
Simulation of proton and alpha particle beams was conducted using the Monte Carlo method via FLUKA software to model cellular responses.
Findings highlight significant differences in energy deposition and DNA damage types, which could enhance radiotherapy approaches.],
simple_explanation
Energy deposition from particles like protons and alpha particles affects DNA in cells. When these particles hit cells with higher energy, more of them can reach the cell's nucleus, where DNA is stored. This study used computer simulations to show how different types of particles deposit energy and cause DNA damage, which matters for improving treatments like radiotherapy. Understanding these interactions helps researchers design better cancer therapies that are more effective and less harmful. 🌟
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Implication

Simulation reveals differences in energy deposition and DNA damage in cellular models with protons and alpha particles, indicating implications for radiotherapy.

Abstract

Microdosimetry is a crucial research area in the development of radiotherapy that aims to understand dose variations at the subcellular level. This work addresses microdosimetry with proton and ion beams, focusing on energy deposition in a cellular geometric model implemented using the Monte Carlo method via FLUKA software. Scenarios were simulated where a proton beam or an alpha particle beam, with energies ranging from 1 to 20 keV, interacted with a simplified cellular model. Detectors were set up to record fluence and energy density in the medium during simulations. The results showed that more particles reached the nucleus as beam energy increased, especially for alpha particles. Energy density analysis revealed that the depth of maximum deposition increases with kinetic energy and was higher for alpha particles. Subsequently, using MCDS (Monte Carlo Damage Simulation) software, dose data from simulations were used to calculate the probability of various DNA damage types—base lesions (BD), single-strand breaks (SSB), and more complex breaks. This study confirmed the effectiveness of the model in simulating microdosimetric effects, highlighting differences in energy deposition and DNA damage between protons and alpha particles. These findings contribute to a better understanding of radiation interactions and the improvement of radiotherapy.

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Cite This Study

Raposo et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2de9 https://doi.org/10.29384/rbfm.2025.v19.19849001796

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Implication

Simulation reveals differences in energy deposition and DNA damage in cellular models with protons and alpha particles, indicating implications for radiotherapy.

Energy Deposition and DNA Damage Analysis of Protons and Alpha Particles simulated with FLUKA applied to a cellular model

Key Points

Implication

Abstract

Discussion

Cite This Study

Energy Deposition and DNA Damage Analysis of Protons and Alpha Particles simulated with FLUKA applied to a cellular model

Key Points

Implication

Abstract

Discussion

Cite This Study

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