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This is a In Vitro Study study (also classified as: Animal Study).

August 26, 2025Journal of the American Society of Nephrology

CREB-Family Transcription Factors and Vasopressin-Mediated Regulation of Aqp2 Gene Transcription

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Deletion of creb-family transcription factors significantly reduced vasopressin-induced AQP2 protein levels, indicating their crucial role.
RNA-seq analysis confirmed that changes in Aqp2 mRNA levels correspond to protein changes, supporting their involvement in regulation.
Using a CRISPR/Cas9 system, transcripts were assessed in mpkCCD cells post-deletion, verifying the importance of ATF1, CREB1, and CREM.
Findings suggest that Aqp2 transcription regulation is not solely dependent on CREB, but rather these transcription factors share overlapping functions.

Authors

AMAdrián Rafael Murillo‐de‐OzoresNational Institutes of Health LCLihe ChenNational Heart Lung and Blood Institute SOShuo‐Ming OuTaipei Hospital

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Implication

Experimental findings reveal vasopressin-induced Aqp2 expression in renal cells relies on three transcription factors, suggesting complex regulatory mechanisms.

Cite This Study

Murillo‐de‐Ozores et al. (2025) studied this question.

synapsesocial.com/papers/68af620aad7bf08b1eae2ef8 https://doi.org/10.1681/asn.0000000822

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Implication

Experimental findings reveal vasopressin-induced Aqp2 expression in renal cells relies on three transcription factors, suggesting complex regulatory mechanisms.

CREB-Family Transcription Factors and Vasopressin-Mediated Regulation of Aqp2 Gene Transcription

Key Points

Discussion

Implication

Cite This Study

CREB-Family Transcription Factors and Vasopressin-Mediated Regulation of Aqp2 Gene Transcription

Key Points

Discussion

Implication

Cite This Study

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