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August 26, 2025LifeOpen Access

Real-World Use of Extended Half-Life Factor IX in Children with Haemophilia B

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Authors

ADAthina DettorakiChildren's Hospital Agia SophiaAMAikaterini MichalopoulouChildren's Hospital Agia SophiaSSStefanos SaslisChildren's Hospital Agia Sophia

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Overview

Retrospective review shows improved outcomes with extended half-life factor IX in children with haemophilia B, indicating enhanced treatment efficacy.

Key Points

  • Children using extended half-life factor IX experienced a drop in their mean annual bleeding rate from 1.8 to 1, showcasing improved treatment effectiveness.
  • The study involved fourteen males with severe bleeding phenotypes, with median follow-up time of 45 months, highlighting longitudinal data on treatment outcomes.
  • Transitioning to extended half-life prophylaxis led to a significant increase in mean trough levels from 4.3% to 15.3%, indicating better management of haemophilia B.
  • Factor IX consumption for prophylaxis reduced significantly from 66.0 IU/kg/week to 37.0 IU/kg/week, emphasizing the cost-effectiveness of extended half-life therapies.

Cite This Study

Dettoraki et al. (2025) studied this question.

synapsesocial.com/papers/68af6210ad7bf08b1eae3271https://doi.org/10.3390/life15091352
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Extended Half-Life Factor Concentrates in Haemophilia Treatment2026 · 1 citations
  2. 2Experience of tertiary prophylaxis with extended half-life factor prophylaxis in India2024
  3. 3Use of extended half-life factor IX products in the surgical setting: case series from a UK haemophilia centre2025
  4. 4Six-Year, Real-World Use of Prophylaxis with Recombinant Factor IX–Albumin Fusion Protein (rIX-FP) in Persons with Hemophilia B: A Single-Center Retrospective–Prospective Study2024 · 7 citations
  5. 5Changes in Quality of Life, Adherence, and Kinesiophobia in Patients with Hemophilia Treated with Extended Half-Life Treatment: Final Results of the LongHest Project2024 · 5 citations