Advances and Challenges in Pediatric Helicobacter pylori-Negative Eosinophilic Gastritis: From Th2-Driven Pathogenesis to Precision Medicine Management
Review highlights Th2-driven immunopathogenesis and diagnostic challenges in pediatric eosinophilic gastritis, suggesting new therapeutic approaches.
Key Points
Eosinophilic gastritis presents significant diagnostic challenges due to heterogeneous symptoms and limited treatment options, requiring individualized strategies.
Key cytokines, particularly IL-5 and IL-13, drive the Th2-skewed immunopathogenesis of eosinophilic gastritis, impacting mucosal integrity.
Diagnostic frameworks incorporating high-resolution endoscopy and molecular biomarkers have improved sensitivity and specificity for eosinophilic gastritis.
Standardized outcome metrics and long-term safety data remain critical obstacles, highlighting the need for precision medicine approaches in treatment.