What type of study is this?

This is a In Vitro Study study (also classified as: Observational).

August 26, 2025Frontiers in ImmunologyOpen Access

Decoding the hypoxic tumor microenvironment in colorectal cancer for prognostic modeling and therapeutic target discovery

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Single-cell analysis reveals a hypoxia-related gene signature for colorectal cancer prognosis, suggesting GIPC2 as a therapeutic target.

A hypoxia-related gene signature predicted overall survival in colorectal cancer patients, highlighting its significance for personalized treatment.
The eight-gene prognostic model stratified patients into distinct risk groups, showing significant differences in survival in both TCGA and validation cohorts.
Analysis involved integrating single-cell RNA sequencing data from colorectal cancer samples to identify hypoxia-related genes and pathways.
Identifying GIPC2 as a potential therapeutic target may provide new insights into hypoxia-driven biology in colorectal cancer.

Duan et al. (2025) studied this question.

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