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August 26, 2025Scientific ReportsOpen Access

Exploring novel thiazolo5,4-fquinoline-based scaffolds as promising antimicrobial agents through synthesis and molecular insights

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Authors

NSNanees N. SolimanAFAhmed A. FaddaHGHatem E. Gaffer

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Overview

Synthesis of thiazolo[5,4-f]quinoline derivatives shows potent antimicrobial activity against Staphylococcus aureus and Escherichia coli, suggesting novel drug development potential.

Key Points

  • Compounds 18, 19, and 23 exhibited potent antimicrobial activity, outperforming chloramphenicol with MIC values of 3.125-6.25 µg/mL.
  • Structure-activity relationship analysis revealed that specific substituents enhance antimicrobial potency significantly.
  • Molecular docking studies indicated that compound 19 showed the strongest binding affinity to bacterial DNA gyrase.
  • Novel thiazoloquinoline structurally enhances potential new antimicrobial drugs; further research is warranted.

Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/68af63d7ad7bf08b1eae3cbahttps://doi.org/10.1038/s41598-025-16561-w
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