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August 26, 2025BioengineeringOpen Access

Chemical Deuteration of α-Amino Acids and Optical Resolution: Overview of Research Developments

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This review highlights chemical deuteration and stereoselectivity in α-amino acids, indicating advancements in scalable protocols.

Deuterium labeling enables new applications in pharmaceutical research and mass spectrometry, enhancing drug metabolism analysis.
Metal-catalyzed H/D exchange was efficiently performed under hydrothermal conditions, showcasing its applicability in amino acid synthesis.
Various methods developed for selective and perdeuterated amino acids indicate progress in achieving optically pure compounds.
Implications of these advancements point to new possibilities in biomolecular structuring and enhanced resolution of amino acid enantiomers.

Nageshwar R. Yepuri (2025) studied this question.

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