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This is a In Vitro Study study (also classified as: Animal Study).

August 26, 2025Journal of Enzyme Inhibition and Medicinal ChemistryOpen Access

Bio-guided discovery of antibacterial metabolites from Penicillium chrysogenum

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Two new metabolites were discovered from Penicillium chrysogenum, showing promising antibacterial activity against various bacteria types.
Compound 6 inhibited Gram-positive and Gram-negative bacteria with MIC as low as 0.15 μM, demonstrating its broad-spectrum efficacy.
Molecular docking identified compounds as potential NDM-1 inhibitors, with molecular dynamics simulations confirming stability in the active site.
Low cytotoxicity was observed for several compounds toward human intestinal epithelial cells, highlighting their safety for potential use.

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Implication

Bio-guided isolation reveals new metabolites with antibacterial activity against Gram-positive and Gram-negative bacteria, suggesting potential against antibiotic resistance.

Cite This Study

Mira et al. (2025) studied this question.

synapsesocial.com/papers/68af63ddad7bf08b1eae417c https://doi.org/10.1080/14756366.2025.2547258

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Implication

Bio-guided isolation reveals new metabolites with antibacterial activity against Gram-positive and Gram-negative bacteria, suggesting potential against antibiotic resistance.

Bio-guided discovery of antibacterial metabolites from Penicillium chrysogenum

Key Points

Discussion

Implication

Cite This Study

Bio-guided discovery of antibacterial metabolites from Penicillium chrysogenum

Key Points

Discussion

Implication

Cite This Study

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