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August 26, 2025American Journal of Clinical DermatologyOpen Access

Management of Erythrodermic Psoriasis with Systemic Therapies: A Systematic Review

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Authors

LMLuca MastorinoFLFrancesco LeoPFPaolo Frigatti

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Overview

Systematic review highlights efficacy of systemic therapies in erythrodermic psoriasis, suggesting treatment pathways.

Key Points

  • Systemic therapies show over 60% clinical response rate in erythrodermic psoriasis, indicating effective management options.
  • Methotrexate and cyclosporine are the most reported non-biologic agents, with cyclosporine providing faster relief.
  • Inhibitors of TNF-α demonstrate better outcomes compared to other biologics, with infliximab being the most reported treatment.
  • Findings are limited by low statistical power and small sample sizes, recommending careful interpretation and further research.

Cite This Study

Mastorino et al. (2025) studied this question.

synapsesocial.com/papers/68af63e3ad7bf08b1eae419fhttps://doi.org/10.1007/s40257-025-00977-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic Treatment and Outcome in Erythrodermic Psoriasis: A Retrospective Multicenter Study2026
  2. 2Advancing Therapeutic Horizons in Erythrodermic Psoriasis: A Comprehensive Review of Pathophysiology, Biomarkers, and Novel Treatments2025
  3. 3Systemic Treatment and Outcome in Erythrodermic Psoriasis: A Retrospective Multicenter Study2026
  4. 4Biologic anti-IL17 drugs in erythrodermic psoriasis2024 · 2 citations
  5. 5An Unusual Presentation of Erythrodermic Psoriasis2024 · 1 citations