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Comment addresses nutritional index and inflammatory biomarkers' roles in predicting thromboembolic events and mortality, highlighting multicollinearity concerns.
We read with interest the study by Mureșan et al. on nutritional and inflammatory biomarkers predicting thromboembolic events and mortality in COVID-19 patients. The simultaneous independent significance of eight correlated biomarkers raises concerns about possible multicollinearity. We welcome the authors’ clarification and updated multivariate results, which confirmed that several markers lost significance after adjustment. We recommend clearer statistical terminology and parallel reporting of univariate and multivariate results to improve transparency.
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Lian et al. (2025) studied this question.
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