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August 26, 2025PharmaceuticsOpen Access

Exploring Experimental and Statistical Approaches to Control Oversensitivity of In Vitro Permeability to Excipient Effects

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Authors

MGMauricio A. GarcíaPontificia Universidad Católica de ChileAAAlexis AceitunoInstituto de Salud Pública de ChileNDNicole Diaz

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Overview

Analysis highlights excipient effects on drug permeability in vitro, suggesting ANOVA improves control over sensitivity.

Key Points

  • Drug permeability analysis showed excipient effects significantly alter outcomes, particularly with sodium lauryl sulfate.
  • Acyclovir and hydrochlorothiazide exhibited varying interactions with excipients, showcasing differing sensitivities.
  • Method evaluation found CI90 more sensitive than ANOVA, identifying 41 vs. 32 excipient effects on permeability.
  • ANOVA generally reduced oversensitivity in in vitro assays, indicating its preferable use for comparing formulations.

Cite This Study

García et al. (2025) studied this question.

synapsesocial.com/papers/68af63e3ad7bf08b1eae4407https://doi.org/10.3390/pharmaceutics17091110
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intestinal Permeability Study of Minoxidil: Assessment of Minoxidil as a High Permeability Reference Drug for Biopharmaceutics Classification2014 · 23 citations
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  3. 3The Effect of Excipients on the Permeability of BCS Class III Compounds and Implications for Biowaivers2015 · 69 citations