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This is a Animal Study study (also classified as: In Vitro Study).

August 26, 2025Nature MethodsOpen Access

Reconstruction of a connectome of single neurons in mouse brains by cross-validating multi-scale multi-modality data

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Cross-validation identifies strong modular diversity in neural connections among 20,247 neurons, highlighting gene coexpression implications.

Single-neuron connections show strong correlations with gene coexpression, surpassing mesoscale connectome relationships.
The inferred connectome integrates data from 20,247 neurons and 2.57 million axonal boutons across light microscopy datasets.
Probabilistic pairing of dendritic and axonal arbors enabled the creation of detailed connectome representations.
Network analysis revealed nonrandom patterns and modular structures indicative of functional organization in the mouse brain.

Xiong et al. (2025) studied this question.

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Cross-validation identifies strong modular diversity in neural connections among 20,247 neurons, highlighting gene coexpression implications.