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This is a Literature Review study.

August 26, 2025Orthopaedic SurgeryOpen Access

Pain Phenotype in Knee Osteoarthritis: Implications for Mechanism‐Based Therapy

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This review categorizes pain types in knee osteoarthritis, suggesting tailored treatment strategies for nociceptive and neuropathic pain.

Nociceptive pain classification includes inflammatory, mechanical, and BMLs-related pain, and requires targeted therapies.
Therapies for knee osteoarthritis pain include anti-inflammatory medications for inflammatory pain and rehabilitation for mechanical pain.
Management strategies for neuropathic pain involve tricyclic antidepressants or anticonvulsants, while nociplastic pain benefits from nonpharmacological approaches.
Recognizing mixed pain types is essential for crafting individualized treatment strategies tailored to patient needs.

He et al. (2025) studied this question.

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