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This is a Literature Review study.

SLFN11, far from being limited to responding to cancer DNA damage

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Review highlights the diverse functions of SLFN11 in dna damage response and antiviral responses, indicating its potential in personalized medicine.

SLFN11 is crucial in the dna damage response during replication stress, protecting against cellular stress and contributing to immune regulation.
It serves as a valuable biomarker for predicting treatment efficacy of dna-damaging agents in various cancers, improving patient prognosis.
The review discusses epigenetic modifications that regulate SLFN11 expression, emphasizing its non-canonical functions and relevance in immunotherapy.
SLFN11's potential applications in personalized medicine face challenges, including the need for precise detection methods and addressing low expression issues.

Xiao et al. (2025) studied this question.

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View Full Paper

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Authors

Review highlights the diverse functions of SLFN11 in dna damage response and antiviral responses, indicating its potential in personalized medicine.

SLFN11 is crucial in the dna damage response during replication stress, protecting against cellular stress and contributing to immune regulation.
It serves as a valuable biomarker for predicting treatment efficacy of dna-damaging agents in various cancers, improving patient prognosis.
The review discusses epigenetic modifications that regulate SLFN11 expression, emphasizing its non-canonical functions and relevance in immunotherapy.
SLFN11's potential applications in personalized medicine face challenges, including the need for precise detection methods and addressing low expression issues.

Xiao et al. (2025) studied this question.

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