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August 25, 2025Open Access

The Influence of Defining Desired Outcomes on Prediction Algorithms: Mass Spectral Analysis of Spent Blastocyst Media in Ai/ML Prediction of IVF Embryo Implantation or Viability, or Both?

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Authors

RIRay K. IlesRZRaminta ZmuidinaiteJIJason K. Iles

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Overview

Analysis reveals predictive algorithms improve implantation and viability outcomes in IVF blastocysts, indicating the need for precise definitions.

Key Points

  • A combined algorithm achieved an 83.5% positive predictive value for identifying viable implanting blastocysts, showcasing the effectiveness of AI/ML in IVF.
  • Mass spectrometry and metabolomic analysis provided extensive datasets for AI/ML predictive algorithms focused on implantation and viability criteria.
  • The importance of accurately defining success outcomes is emphasized, as premature definitions can lead to misinterpretation and reduced clinical efficacy.
  • Current IVF approaches must integrate trophoblast metabolic features and inner cell mass markers for better embryo viability assessments.

Cite This Study

Iles et al. (2025) studied this question.

synapsesocial.com/papers/68af63efad7bf08b1eae4bdbhttps://doi.org/10.20944/preprints202508.1774.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Development of a Robust and User Friendly Preimplantation Metabolic Test of Blastocyst Competence, PMT-BC: Mass Spectral Analysis of Spent Blastocyst Media in Ai/ML-Bayesian Prediction of IVF Embryo Implantation Potential2025
  2. 2The Development of a Robust and User Friendly Preimplantation Metabolic Test of Blastocyst Competence, PMT-BC: Mass Spectral Analysis of Spent Blastocyst Media in Ai/ML-Bayesian Prediction of IVF Embryo Implantation Potential2025
  3. 3The Influence of Hatching on Blastocyst Metabolomic Analysis: Mass Spectral Analysis of Spent Blastocyst Media in Ai/ML Prediction of IVF Embryo Implantation Potential– To Hatch or Not to Hatch?2025
  4. 4Validation of the PMT-BC Test: Mass Spectral Analysis of Spent Blastocyst Media for Prediction of IVF Blastocyst-Embryo Implantation Potential2025
  5. 5O-297 Prediction of pregnancy outcomes of single vitrified-warmed blastocyst transfer using combination of an automatic classification algorithm applied on cleavage stage embryos and blastocyst morphology2024