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Nutrients as epigenetic modulators in metabolic dysfunction-associated steatotic liver disease

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Review highlights dietary epigenetic modulation's role in metabolic dysfunction and steatotic liver disease.

Epigenetic regulation plays a crucial role in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), linking diet and disease development.
Key mechanisms include DNA methylation and histone modification, which regulate gene expression without altering the DNA sequence itself.
The impact of MASLD extends beyond liver health, affecting patients and healthcare systems significantly.
Diet, particularly the Westernized diet, is implicated in the pathogenesis of MASLD through various epigenetic pathways.

Rodríguez et al. (2025) studied this question.

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View Full Paper

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Authors

Review highlights dietary epigenetic modulation's role in metabolic dysfunction and steatotic liver disease.

Epigenetic regulation plays a crucial role in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), linking diet and disease development.
Key mechanisms include DNA methylation and histone modification, which regulate gene expression without altering the DNA sequence itself.
The impact of MASLD extends beyond liver health, affecting patients and healthcare systems significantly.
Diet, particularly the Westernized diet, is implicated in the pathogenesis of MASLD through various epigenetic pathways.

Rodríguez et al. (2025) studied this question.

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