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P128 | Beyond thresholds: hyperviscosity syndrome in Waldenström’s macroglobulinemia - A Case report

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Case report reveals hyperviscosity syndrome in a patient with Waldenström’s macroglobulinemia, suggesting timely intervention is crucial.

Hyperviscosity syndrome was diagnosed after identifying specific symptoms and blood tests results, indicating immediate treatment was necessary.
The patient's levels of immunoglobulin were below the typical threshold for hyperviscosity syndrome, yet symptoms persisted, highlighting complexity in diagnosis.
The treatment involved three sessions of plasmapheresis, resulting in complete regression of symptoms within a short timeframe.
This case underscores the importance of recognizing hyperviscosity syndrome in paraprotein-secreting hematologic malignancies, regardless of immunoglobulin levels.

A 2025 study studied this question.

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Case report reveals hyperviscosity syndrome in a patient with Waldenström’s macroglobulinemia, suggesting timely intervention is crucial.