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October 10, 2024Journal of Research in Pharmacy0 citationsOpen Access

Expression of Matrix Metalloproteinases in Placenta of Women with Miscarriage

Immunohistochemical study of matrix metalloproteinases 2 and 9 in the placenta of spontaneous miscarriage

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Authors

RHRafla HassanMHMukhtar K. Haba

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Overview

Immunohistochemical analysis shows altered MMP-2 and MMP-9 levels in placenta of women with spontaneous miscarriage, suggesting roles in embryo implantation and placentation.

Key Points

  • MMP-2 and MMP-9 showed strong expression in the placenta of normally delivered women, unlike in miscarriage cases.
  • In first-trimester miscarriage, about 60% exhibited weak expression of MMP-2, highlighting abnormalities in expression.
  • Immunohistochemical analysis was performed on placental specimens from 90 women across normal and miscarriage groups.
  • The findings may suggest that altered MMP expression could be linked to miscarriage, warranting further investigation.
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Cite This Study

Hassan et al. (2024) studied this question.

synapsesocial.com/papers/68af6595ad7bf08b1eae5240https://doi.org/10.12991/jrespharm.1766301
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