Key result
PROM with subclinical chorioamnionitis is linked to higher MMP-9 expression than PROM alone or intact membranes.
Why the study?
Increased knowledge of MMP-9 expression in cases of premature rupture of membranes with and without chorioamnionitis is essential for developing effective treatment strategies.
Is MMP-9 expression increased in pregnant women with premature rupture of membranes (PROM) and chorioamnionitis compared to those with intact membranes?
Observational (n=70)
Is MMP-9 expression increased in pregnant women with premature rupture of membranes (PROM) and chorioamnionitis compared to those with intact membranes?
MMP-9 expression in maternal serum and fetal membranes is significantly elevated in premature rupture of membranes, particularly when complicated by subclinical chorioamnionitis, suggesting its potential utility as a biomarker.
Elevated MMP-9 may flag subclinical chorioamnionitis in PROM; leaves open biomarker utility pending prospective validation.
Background: Matrix metalloproteinase-9 (MMP-9) is the most active MMPs in the fetomaternal membranes. It plays an important role in the breakdown and remodeling of these membranes. Thus, increased knowledge of its expression in cases of premature rupture of membranes (PROM) with and without chorioamnionitis (CA) is essential for developing effective treatment strategies. Patients and Methods: expression of MMP-9 in fetomaternal membranes and maternal serum were performed in 70 full-term pregnant women; 20 cases were with intact membranes (group I), 35 with PROM (group IIA) and 15 with PROM and CA (group IIB). Results: A significant difference in MMMP-9 expression was detected between the studied groups. The highest MMP-9 expression was reached in women with PROM accompanied by histological (subclinical) CA followed by women with PROM without CA, compared to the control group (with intact membranes) at the time of delivery. Immunohistochemical expression was associated with a concomitant increase in serum MMP-9. Conclusion: MMP-9 could predict women liable for premature rupture of membranes, and the determination of its serum level may be an effective tool for PROM detection.
No takes yet. Share an insight, caveat, or question.
Harras et al. (2021) conducted an observational in Premature rupture of membranes (n=70). Premature rupture of membranes with or without chorioamnionitis vs. Intact membranes was evaluated on MMP-9 expression in fetomaternal membranes and maternal serum. MMP-9 expression was significantly higher in women with premature rupture of membranes and subclinical chorioamnionitis compared to those with PROM alone or intact membranes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: