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September 26, 2024Journal of Research in PharmacyOpen Access

Enhanced cytotoxicity of docetaxel delivered through folic acid grafted poloxamer P188 polymeric micelles

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Authors

ATAmol TatodeDZDivya ZambreMQMohammad Qutub

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Overview

In vitro evaluation reveals improved cytotoxicity of docetaxel in cancer cells using folic acid-conjugated micelles, indicating potential for targeted therapy.

Key Points

  • FA-P188-DTX micelles achieved enhanced cytotoxicity in MDA-MB-231 breast cancer cells compared to standard docetaxel treatment.
  • Entrapment efficiency exceeded 75% with micelle sizes under 200 nm, suggesting efficient drug delivery and targeting.
  • Characterization involved dynamic light scattering and UV spectroscopy, demonstrating stable drug encapsulation with desirable properties.
  • These findings support the potential of FA-P188 micelles for targeted cancer therapy, highlighting their sustained release capabilities and targeting design.

Cite This Study

Tatode et al. (2024) studied this question.

synapsesocial.com/papers/68af6595ad7bf08b1eae5246https://doi.org/10.12991/jrespharm.1766361
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