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P145 | Persistent fever of unknown origin and bilinear cytopenia of new onset in healthy woman

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Elevated inflammatory biomarkers accompanied by skin ulcer led to a diagnosis of acute myeloid leukaemia.
Patient presented with leukocytosis and elevated CRP, followed by identification of NPM1 mutation revealing AML.
Bone marrow biopsy confirmed acute myeloid leukaemia, prompting treatment with steroids and azacitidine.
Swift resolution of fever and biomarkers post-treatment highlights the need for timely diagnosis in complex cases.

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Case report reveals acute myeloid leukaemia diagnosis through persistent fever and skin ulcer, suggesting new treatment approaches.

A 2025 study studied this question.

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