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September 5, 2025Scientific ReportsOpen Access

RAD18 methylation by the methyltransferase SETD6 attenuates DNA breaks

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Authors

LWLital Estrella WeilMFMichal FeldmanJDJennifer Van Duine

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Overview

Research reveals that SETD6 regulates RAD18 through methylation, impacting DNA damage response and localization.

Key Points

  • SETD6-mediated methylation of RAD18 is crucial for minimizing DNA breaks and maintaining genomic stability.
  • Monitoring RAD18 via comet assays revealed that SETD6 KO led to increased DNA damage markers such as γH2AX.
  • The interaction between SETD6 and RAD18 was confirmed through techniques like ELISA and immunoprecipitation.
  • Methylation at residues K73 and K406 of RAD18 influences its nuclear localization and functional dynamics.

Cite This Study

Weil et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a2b2b87ece8dc95493chttps://doi.org/10.1038/s41598-025-16908-3
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