This study uncovers palladium-catalyzed dearomatization that constructs fused polycyclic skeletons from naphthalenes and benzenes, suggesting broad functional group compatibility.
A novel palladium-catalyzed dearomative cyclization of naphthalenes and benzenes has been accomplished for the expedient construction of fused polycyclic skeletons bearing an all-carbon quaternary center. Excellent functional group tolerance was demonstrated in the reaction of 2,2-phenylnaphthyl acetonitriles, in which the cyano group can serve as a linkage for potential applications. In addition, the challenging dearomatization of benzenes was developed, offering [6,5,6]-carbotricyclic scaffolds that may play a role as an intermediate for the synthesis of fused tricyclic natural products and analogues.
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Li et al. (2025) studied this question.
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