Visible-light-induced asymmetric dearomative hydroalkylation improves chiral indoline synthesis, highlighting novel catalysis methods.
A visible-light-induced catalytic asymmetric dearomative hydroalkylation of electron-deficient indole derivatives with potassium alkyltrifluoroborates was realized under mild reaction conditions. A synergistic catalyst system involving organo-photocatalyst and chiral Lewis acid was employed to enable high efficiency and excellent stereocontrol, delivering a range of chiral 2,3-disubstituted indolines. Mechanistic studies revealed an oxidation-quenching-triggered enantioselective radical coupling/protonation cascade.
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Zhu et al. (2025) studied this question.
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