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September 5, 2025Cell Reports MedicineOpen Access

Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma

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Authors

HWHui WanKarolinska Institutet WRWeicheng RenKarolinska Institutet MYMing‐Yu YangThe Affiliated Yongchuan Hospital of Chongqing Medical University

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Implication

Analysis reveals unique evolutionary paths and immune microenvironment alterations in mantle cell lymphoma, indicating significant tumor evolution during disease progression.

Key Points

Tumor evolution in mantle cell lymphoma shows significant intratumor heterogeneity at diagnosis, highlighting diversity in cancer behavior.
Whole-genome sequencing and single-cell RNA sequencing uncovered unique evolutionary paths in 11 patients, with varying mutations and copy number changes.
Recurrent genetic changes in tumor cells were identified, affecting key signaling pathways and the tumor microenvironment during disease progression.
Findings emphasize the complex dynamics of tumor-immune interactions, which may influence treatment responses and prognosis.

Cite This Study

Wan et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a3d2b87ece8dc95506a https://doi.org/10.1016/j.xcrm.2025.102318

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Implication

Analysis reveals unique evolutionary paths and immune microenvironment alterations in mantle cell lymphoma, indicating significant tumor evolution during disease progression.

Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Tumor evolution and immune microenvironment dynamics in primary and relapsed mantle cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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