Oliceridine: Progress in Clinical Research on a New Analgesic Drug

Oliceridine is a new class of μ-opioid receptor agonists, which is relatively selective to μ-opioid receptors and exerts analgesic effects by interacting with μ-opioid receptors (MORS). Compared with morphine, it has the characteristics of fast onset, strong analgesic effect, low incidence of respiratory depression and gastrointestinal adverse reactions, and less neurological complications. It is a safe and effective intravenous analgesic, providing a better choice for the treatment of patients with moderate to severe acute pain. In this paper, the mechanism of action, pharmacodynamics and pharmacokinetics, clinical application and development trend of oliceridine were reviewed, so as to provide theoretical basis for clinical application.