Domino Cu-catalyzed approach generates diverse 3-acylated benzofurans, highlighting substrate scope and functional group tolerance.
A domino Cu-catalyzed nucleophilic cyclization and C-C bond activation to access various 3-acylated benzofurans has been developed. The in situ generated benzofuranylcopper intermediate was coupled with cyclopropenone, wherein the ring-opening of cyclopropenone with phenol was effectively suppressed. This strategy features excellent substrate scope, good functional group tolerance, and high atomic economy.
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Zhou et al. (2025) studied this question.
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