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September 5, 2025International Journal of Molecular SciencesOpen Access

Human Serum Albumin-Based Nanoparticles for Targeted Intracellular Drug Delivery

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Authors

CCClaudia G. ChilomSISorina IftimieABAdriana Bălan

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Overview

Synthesis of folic acid-conjugated nanoparticles showed enhanced targeted drug delivery in colorectal cancer cells.

Key Points

  • HSA-FA:Ru nanoparticles significantly reduced the viability of HT-29 cancer cells, showing potential for anticancer delivery.
  • MTS assays demonstrated that nanoparticles preferentially targeted and accumulated in HT-29 colon adenocarcinoma cells.
  • Fabrication involved a desolvation method, producing stable nanoparticles below 100 nm for effective drug delivery.
  • The findings highlight the capability of albumin-based nanocarriers for targeted therapeutic applications in cancer treatment.

Cite This Study

Chilom et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a492b87ece8dc955737https://doi.org/10.3390/ijms26178297
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  1. 1Research progress of serum albumin in the field of drug delivery2024 · 12 citations
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  4. 4Serum Albumin Nanoparticles: Problems and Prospects2021 · 95 citations
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