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September 5, 2025PeerJOpen Access

The role of N6-methyladenosine (m6A) RNA methylation modification in kidney diseases: from mechanism to therapeutic potential

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Authors

SGShao-wen GuoWWWenjun WangGLGang Lv

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Overview

Review unveils m6A RNA modification's influence on gene expression in kidney diseases, highlighting therapeutic potential.

Key Points

  • m6A methylation significantly impacts kidney disease mechanisms and may enhance treatment approaches.
  • Alterations in m6A modification levels correlate with severity in acute kidney injury and chronic kidney disease.
  • Regulators like METTL3 and FTO are pivotal in modulating gene expression related to kidney pathology.
  • Emerging studies indicate that m6A modifications are crucial across various kidney disease types.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a492b87ece8dc9557b1https://doi.org/10.7717/peerj.19940
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