pH metric titration reveals metal-ligand stability constants in mixed solvent systems, suggesting key thermodynamic insights.
We have used a pH metric titration technique in a 20% (v/v) ethanol-water mixture at three different temperatures at an ionic strength of 0.1M NaClO4 to measure the proton-ligand and metal-ligand stability constants of medicinal drugs containing Gadolinium metal ion (Gd3+). The logK values of the metal-ligand stability constant have been determined using the modified Irving-Rossotti and Calvin-Bjerrum method. The thermodynamic parameters Gibb's free energy change, entropy change and enthalpy change related to the complexation reactions were quantitatively determined.
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Sampal et al. (2025) studied this question.
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