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September 5, 2025Journal of Pharmacy & Pharmacognosy Research

Efficacy of Gynura procumbens (Lour.) Merr. extract in enhancing diabetic wound healing through modulation of IL-1β, PDGFβ, and TGF-β in a rat model

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Authors

WDWhika Febria DewatisariPSPutri Cahaya SitumorangASAndina Setyawati

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Overview

Controlled trial showed Gynura procumbens enhances wound healing in diabetic rats by reducing IL-1β, indicating its therapeutic potential.

Key Points

  • The extract significantly increased epithelial thickness and fibroblast density in diabetic wounds.
  • At a dose of 200 mg/kg BW, IL-1β levels decreased by 45% while PDGFβ and TGF-β increased by 60% and 70%, respectively.
  • Observational analysis of diabetic rat models demonstrated improved healing with Gynura procumbens extract compared to standard treatments.
  • Findings support Gynura procumbens as a promising natural option for promoting healing in chronic wounds.

Cite This Study

Dewatisari et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d4e2b87ece8dc955dc2https://doi.org/10.56499/jppres24.2259_13.6.1776
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Also Consider

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  1. 1A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats2024
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  4. 4Enhanced Fibrogenesis Activity in Diabetic Wound Using 20% Anredera scandens (L.) Moq. Leaves Extract Ointment in Sprague dawley Rats2024
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