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September 5, 2025Frontiers in Molecular BiosciencesOpen Access

Editorial: Plasticity of the haematopoietic niche: from embryonic development to aging and disease

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Authors

RSRyohichi SugimuraAFA FidanzaEAEmanuele Azzoni

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Overview

Editorial reviews the plasticity in haematopoietic niches influencing stem cell behavior and disease implications.

Key Points

  • Haematopoiesis exhibits significant changes from embryonic development through adulthood, impacting stem cell function.
  • Recent findings show a progressive decline in total haematopoietic activity in the liver during the third trimester.
  • Single-cell transcriptomics has advanced insights into haematopoietic niches, revealing cellular composition evolution.
  • Niche plasticity is crucial for developing effective treatments for haematological diseases and stem cell expansion.

Cite This Study

Sugimura et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d4e2b87ece8dc955dd2https://doi.org/10.3389/fmolb.2025.1683902
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