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September 5, 2025Frontiers in GeneticsOpen Access

Identification and validation of a histone modification-related gene signature to predict the prognosis of multiple myeloma

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Authors

JLJuan LyuSLShaoyu LyuYQYing Qian

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Overview

Development of a prognostic model reveals significant survival differences in multiple myeloma patients, suggesting improved risk stratification.

Key Points

  • The HMR risk score successfully stratified patients into high-risk and low-risk groups, indicating distinct survival outcomes.
  • Identified seven histone modification-related genes, demonstrating their prognostic significance in multiple myeloma.
  • Functional analysis indicates the HMR risk score is linked to dysregulated processes, including cell cycle progression and immunosuppression.
  • The nomogram developed offers a practical tool for enhancing individual patient risk assessment and personalized treatment strategies.

Cite This Study

Lyu et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d552b87ece8dc955e47https://doi.org/10.3389/fgene.2025.1613631
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