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September 5, 2025npj Precision OncologyOpen Access

Applying next-generation sequencing to detect microsatellite instability in pan-cancer patients: a retrospective study of 35,563 Chinese cases

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Retrospective analysis reveals MSI's prevalence and discordance in 35,563 Chinese pan-cancer cases, indicating NGS is a valuable tool.

Next-generation sequencing detected microsatellite instability with improved accuracy over traditional methods, enhancing diagnostic capabilities.
In a cohort of 35,563 Chinese pan-cancer cases, our analysis identified key MSI-associated genes that may influence treatment decisions.
A novel algorithm was applied for detecting MSI, successfully evaluating discrepancies between PCR and NGS methods in a wide array of cancer types.
Findings suggest the potential for specific microsatellite loci to serve as standardized markers in pan-cancer MSI detection.

Shang et al. (2025) studied this question.

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