Comparative analysis reveals differing impacts of non-selective NSAIDs on gastric mucosa in Wistar rats, suggesting aspirin poses the least risk.
Key Points
All NSAID-treated groups exhibited significant gastric damage compared to the control group, indicating substantial side effects from these drugs.
Among the tested NSAIDs, diclofenac sodium and piroxicam caused the most pronounced hemorrhagic injury and mucosal edema, respectively, highlighting their risks.
Ibuprofen led to the highest level of inflammatory cell infiltration, indicating its potential for severe gastrointestinal side effects.
Aspirin resulted in the least histopathological damage score among the NSAIDs tested, suggesting it may pose a lower risk of gastric injury.