Fast and selective protein modification with iron-substituted polyoxometalates via a radical pathway

Mhamad Aly Moussawi; Shorok A. M. Abdelhameed; Francisco de Azambuja; Andy Wijten; Tamara Vasović; Tanja Ćirković Veličković; Tatjana N. Parac‐Vogt

doi:10.1039/d5qi01454a

January 1, 2025Inorganic Chemistry FrontiersOpen Access

Fast and selective protein modification with iron-substituted polyoxometalates via a radical pathway

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Key Points

The method achieves fast oxidative cleavage of proteins, enhancing selectivity at binding sites.
Iron-substituted polyoxometalates exhibit both Lewis acidity and redox activity, critical for the reaction.
Regioselective hydrolytic and oxidative cleavages occur, with oxidative processes being significantly faster.
The findings suggest that these polyoxometalate clusters can be pivotal in advanced protein engineering.

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Implication

This approach demonstrates rapid oxidative cleavage of proteins in the presence of iron-substituted polyoxometalates, indicating high regioselectivity.

Abstract

Leveraging the Lewis acidity and redox activity of Fe-substituted polyoxometalate clusters facilitates the regioselective hydrolytic (slow) or oxidative (fast) cleavage of proteins near their binding sites.

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Cite This Study

Moussawi et al. (2025) studied this question.

synapsesocial.com/papers/68bb3edf2b87ece8dc956cc3 https://doi.org/10.1039/d5qi01454a

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Fast and selective protein modification with iron-substituted polyoxometalates via a radical pathway

Key Points

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Implication

Abstract

Discussion

Cite This Study

Fast and selective protein modification with iron-substituted polyoxometalates via a radical pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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