This method generates elusive iminyl and endocyclic 1-azaallyl radicals, suggesting new applications in synthesis.
A catalyst-free method has been discovered based on photoexcited electron donor-acceptor complexes to generate an iminyl radical and endocyclic 1-azaallyl radicals, elusive intermediates that have never been reported in synthesis. The two radicals then combine and, following reduction, ultimately provide unprotected 2-(hetero)aryl-3-aminopiperidines. This reaction expands the knowledge and synthetic application of endocyclic 1-azaallyl synthons with an intrinsic ring strain.
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Zhang et al. (2025) studied this question.
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