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A Computationally Optimized Ribonucleic Acid Circularization Strategy without Byproducts

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The method achieves high circularization efficiency for RNA sequences ranging from dozens to thousands of nucleotides.
Automated computational optimization maximizes circularization, particularly for longer RNA substrates.
This purification-free strategy simplifies production by eliminating excess nucleic acid components.
The approach results in circular RNAs that enhance stability and translation efficiency, improving mRNA therapeutic applications.

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This approach demonstrates efficient circularization of RNA in vitro, suggesting improvements for mRNA therapies.

Chen et al. (2025) studied this question.

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