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September 5, 2025Terapevticheskii arkhivOpen Access

Serological markers as predictors of the severity of gastric mucosal atrophy in autoimmune and Helicobacter рylori-associated gastritis

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Serum pepsinogens can predict severe gastric mucosal atrophy stages III–IV, particularly in autoimmune gastritis.
In patients with autoimmune gastritis, a PG I/PG II ratio ≤ 3 indicated severe atrophy in 70.21% of cases.
GastroPanel biomarkers showed a sensitivity of 75.81% for PG I ≤ 30 μg/L, effectively identifying at-risk patients.
These findings highlight the potential of serological markers in non-invasive gastric cancer screening.

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Evaluation of serum markers identifies high-risk groups for gastric cancer in patients with gastritis, suggesting targeted endoscopic screening.

Chebotareva et al. (2025) studied this question.

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Evaluation of serum markers identifies high-risk groups for gastric cancer in patients with gastritis, suggesting targeted endoscopic screening.