Case series shows early diagnosis of multiple sclerosis in patients with atypical symptoms, suggesting DIR MRI can enhance detection of lesions.
The choice of additional Double Inversion Recovery (DIR) Magnetic Resonance Imaging (MRI) sequences may affect the judgment of the presence and nature of lesions. Herein, we reported three cases initially presenting with non-typical multiple sclerosis (MS) symptoms, in which the final diagnosis of MS was confirmed after incorporating spinal cord and brain DIR MRI sequence. The sequence revealed more conspicuous lesions compared to conventional T2-weighted imaging or T2-weighted fluid-attenuated inversion recovery (T2WI/FLAIR) sequences. Consequently, the patients received an earlier definitive diagnosis and timely treatment. Our cases demonstrated the additional DIR sequences for the patients with non-typical MS symptoms were reasonable and may be helpful.
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: